Dr. Claudia Aloisi
Dr. Claudia Aloisi
Staff of Professorship for Toxicology
Additional information
Research area
DNA damage Repair and Mutagenesis
- Glycosylase Engineering for DNA damage mapping
- Single-molecule strategies to elucidate the dynamics and kinetics of DNA damage repair at the molecular level (Magnetic Trap and TIRF)
- Investigating the role of DNA repair on the mutagenicity of carcinogens
- Site-specific detection of mutagenic DNA adducts using DNA hybridazing chemical probes
- Transcription-coupled nucleotide excision repair as a basis for cellular resistance to anticancer agents
Research Experience
09/2024 - Present, Senior Scientist, ETH Zurich - Aging and mitochondria: the terrible couple; Glycosylases engineering for DNA damage mapping
01/2021-08/2024, Postdoctoral Researcher, ENS Paris (EMBO fellow, SNSF fellow) - DNA single-strand break repair in cancer and aging: a single-molecule perspective
01/2020-11/2020, Postdoctoral Researcher, ETH Zurich - Hijacking Transcription-Coupled DNA Repair for Cancer Therapy
06-07/2019, Visiting Graduate Researcher, UNIST, Republic of Korea (Young Researchers' Exchange Programme)
05/2015 – 12/2019 Graduate Researcher, ETH Zurich - Thesis title: Gene-targeted identification of DNA lesions to unravel mechanisms of mutagenesis
02-09/2014, Master Thesis Intern, King’s college of London UK - Thesis title: Biotechnological production of Isd11 protein and characterization of its state of aggregation
01-06/2012, Bachelor Thesis Intern, National Research Council, Italy - Thesis title: Synthesis of a folic acid-calix[4]arene conjugate as a cancer imaging agent
Education
05/2015 - 12/2019, PhD in Biochemical Toxicology, ETH Zurich, Switzerland
10/2012 - 12/2014, Master in Organic Chemistry, University of Pisa, Italy
09/2009 - 07/2012, Bachelor in Chemistry, University of Catania, Italy
Membership
| Since | Membership |
|---|---|
| 2025 | Swiss Chemical Society |
| 2018 | Chair of 2020 Gordon Research Seminar on Mutagenesis |
| 2018 | Swiss Society of Toxicology |
| 2017 | Molecular Life Science Lecture Series organizing committee |
| 2017 | Swiss Chemical Society |
Honours
| Year | Distinction |
|---|---|
| 2021 | Schläfli Prize in Chemistry |
| 2021 | SNSF Postdoc.Mobility |
| 2020 | EMBO Long-term postdoctoral fellowship |
| 2019 | Scholarship, Young Researchers' Exchange Programme between Korea and Switzerland |
| 2018 | Travel Grant, Swiss Society of Toxicology |
| 2018 | Conference Grant for discussion leaders, 2018 Gordon Research Seminar on Mutagenesis, Newry, Maine, USA |
| 2018 | Travel Grant, Molecular Life Science |
| 2017 | Travel grant, IUPAC for "Autumn School Chemical Biology", Konstanz, Germany |
| 2016 | Best oral presentation, Symposium "DNA damage response, genetic instability and cancer", Mainz, Germany |
| 2016 | Travel grant, Symposium "DNA damage response, genetic instability and cancer", Mainz, Germany |
| 2014 | Scholarship for Master Thesis, Erasmus Outgoing Consortia Placement |
Additional information
Teaching
2024 - 2025, Teaching Commission deputy representative, HAS Zurich
2023, "Femmes et Sciences” mentoring program 2023, PLS, Paris
2017 - 2020, Devise learning activities and experimental protocol, frontal lecture and supervise students in the laboratory; Nutrition and Toxicology Laboratory Course (Food Science Bachelor, ETHZ)
2018, Organize and co-tutor; Tutorial in Transcription-blocking genotoxic agents in cancer therapy (MLS doctoral program, ETHZ UZH)
2017, Teaching Certificate ETHZ
2016, Proctor and grade exam; Molecular Disease Mechanism (Biology MSc, ETHZ)
2016, Proctor and grade exam; Introduction to Molecular Toxicology (Food Science BSc, ETHZ)
Media
Oligonucleotide Therapeutics Society Webinar, 2022 https://www.oligotherapeutics.org/webinars/
Interview for the Swiss Academy of Sciences (SCNAT), 2021 https://scnat.ch/en/uuid/i/903ba039-9b44-58d4-8561-55bf220a3bd-Claudia_Aloisi_%E2%80%93_Harnessing_the_beauty_of_chemistry
Interview for the “ACS Editors Explore the Power of Female Mentorship in Chemistry”, 2019 https://axial.acs.org/2019/02/11/acs-editors-explore-the-power-of-female-mentorship/