Chemoenzymatic tools for probing DNA-protein interactions
Why does individual genetic variation affect drug response? How does drug resistance develop? What combinations of drugs and diagnostic biomarkers are ideal to address these situations? Precision medicine gives new insights into physiological and molecular mechanism of disease, which is expected to transform drug development and cancer therapy.
Projects
Tailoring DNA Scissors with Engineered High Specificity Glycosylase Enzymes Generating novel glycosylases for diverse biotechnological applications via state-of-the-art protein engineering
Hijacking Transcription-Coupled DNA Repair for Cancer Therapy Overcoming DNA repair as a basis of cellular resistance to acylfulvene anticancer alkylating drugs.
Biomarkers of cancer drug-responses Quantifying molecular markers, including DNA adducts, in biological samples to elucidate impacts on drug safety and efficacy.